Backup quarterback Mac Jones is in line to start for a banged up 49ers team in Week 2 at the New Orleans Saints with Brock Purdy suffering from a shoulder and toe injuries. All eyes on Christian McCaffrey to lead the 49ers offense Sunday vs a Saints defense susceptible to the run. Key matchups and predictions for Week 2. San Francisco 49ers fans are treated to daily news and analysis with Locked On 49ers, hosted by football analyst Brian Peacock and former NFL/AFL cornerback Eric Crocker. Follow & Subscribe on all Podcast platforms…🎧 https://link.chtbl.com/LO49ers?sid=YouTube Locked On NFL League-Wide: Every Team, Fantasy, Draft & More🎧 https://linktr.ee/LockedOnNFL Follow Brian Peacock and Eric Crocker on Twitter, where they’ll be sharing the latest news about the Niners and talking with fans.Twitter: twitter.com/BDPeacock, twitter.com/eric_crocker Listener SurveyWe’ve put together a survey to learn more about our listeners and make your favorite podcasts even better. Go tohttps://lockedonpodcasts.com/survey/ to get started. Everyone who completes a survey will be entered for a chance to win one of ten $100 Amazon gift cards. Support Us By Supporting Our Sponsors! DoorDashWith DoorDash Streaks, you save every Saturday you order — stack it up all season and you could save up to $250. Order this Saturday. Keep the streak alive. Fuel your gameday — only with DoorDash. Terms apply. Promo period through 11/18. Monarch MoneyTake control of your finances with Monarch Money. Use code LOCKEDONNFL at monarchmoney.com/lockedonnfl for 50% off your first year. UpsideDon’t let this offer drive on by, download the free Upside app now using my limited time promo code TOUCHDOWN for a limited time 25 cent per gallon bonus! Offers vary by user and location, Go to upside.com for terms and conditions.Click Here to download the app: https://getupside.onelink.me/zlLr?af_xp=custom&pid=barrington&c=barrington_lockedon25&deep_link_value=promo&deep_link_sub1=lockedon25&af_dp=upsideapp%3A%2F%2F Yahoo FantasyPresented by YahooFantasy #YahooPartner. Draft now at https://yahoofantasy.com/lockedonnfl. PrizePicksDownload the PrizePicks app today and use code LOCKEDONNFL to get $50 in lineups after you play your first $5 lineup. GametimeDownload the Gametime app, create an account, and use code LOCKEDONNFL for $20 off your first purchase. Terms apply. Download Gametime today. What time is it? Gametime. FanDuelRight now, new customers can bet just FIVE dollars and if your bet wins—you’ll get THREE HUNDRED dollars in bonus bets to use across the app. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

The San Francisco 49ers handled business in week one against the Seattle Seahawks, but not without sustaining some lingering injuries to key players. George Kittle has landed on IR, and Brock Purdy is questionable for Sunday's matchup, plus embattled kicker Jake Moody finally gets the axe. With a road matchup against the New Orleans Saints looming, how will the San Francisco 49ers stack up?

Insight from Jake Moody's former teammate with the San Francisco 49ers, Taybor Pepper, after the kicker was waived following Week 1. Pepper speaks about the life of a specialist in the NFL and his sideline confrontation with Deebo Samuel. Also, injury notes on George Kittle and Brock Purdy.

A busy day following the San Francisco 49ers Week 1 win in Seattle as wide receiver Kendrick Bourne rejoins the team on a 1-year deal and right tackle Colton McKivitz signs a 3-year extension worth $45 million. Why these were great moves for the 49ers in the short and longer term.

The San Francisco 49ers open the 2025 season with a thrilling WIN over the Seattle Seahawks. Nick Bosa and Jake Tonges were late heros. George Kittle touchdown before leaving with a hamstring injury. Brock Purdy started hot. Defenses took over in 2nd half. Game balls for Week 1 and MORE!

The San Francisco 49ers escaped Lumen Field with a win over the Seattle Seahawks, thanks to a touchdown drive ending with a Jake Tonges touchdown reception in the final minutes of the fourth quarter. After losing George Kittle to injury earlier in the game, Jake Tonges, who had never recorded a catch in an NFL game before today, was thrust into action and stepped up in the biggest moment of the game. Nick Bosa's strip sack on the following Seattle Seahawks drive was the proverbial nail in the coffin. The win was not without drama, as Jake Moody missed two more field goals today, and the offensive line looked overmatched for a large part of this game.

The San Francisco 49ers face a tough test right off the rip in the 2025 season as they travel to the Pacific Northwest to face the rival Seattle Seahawks. Thankfully for the San Francisco 49ers, starting wide receiver Jauan Jennings reached an agreement with the team on a reworked contract for this season and is back practicing with the team. They will need him to compete with a tough division rival in the season opener on Sunday.

SEAHAWKS vs 49ERS: Week 1 Showdown at Lumen Field. With both teams facing "a lot of familiarity, but a lot of unknowns," this preview offers essential insights for fans. Tune in for expert predictions and learn why red zone performance could be the key to victory in this season opener.

Will the San Francisco 49ers win a sixth Lombardi Trophy after the 2025 NFL season? Predictions fly as "Winkstradamus" Nicholas Winkler joins hosts Brian Peacock and Eric Crocker to forecast the 49ers' path to glory.

GOOD INJURY NEWS for the 49ers (for once!) as not only WR Juan Jennings, but RG Dominick Puni and others hit the practice field in preparation for Week 1 of the NFL season vs the Seattle Seahawks.