Huberman Lab
Huberman Lab
Scicomm Media
Male vs. Female Brain Differences & How They Arise From Genes & Hormones | Dr. Nirao Shah
2 hour 26 minutes Posted Jul 28, 2025 at 8:00 am.
Nirao Shah
Mice, Humans & Brain, Biological Conservation
Hormones, Nature vs Nurture
Biological Sex Differences, Chromosomes & SRY Gene, Hormones
Sponsors: Maui Nui & Eight Sleep
Androgen Mutations, Feminization & Masculinization
SRY Gene; Animals & Sexual Trans-Differentiation
Hormones & Biological Brain Differentiation
Congenital Adrenal Hyperplasia, Androstenedione; Stress & Pregnancy
Genes, Brain Differentiation & Sexual Identity; Congenital Adrenal Hyperplasia
Testosterone, Estrogen & Brain Circuits
Sponsors: AG1 & LMNT
Intersex Individuals, Castration
Female Sexual Behavior, Brain, Testosterone & Pheromones
Identify as Heterosexual or Homosexual, Difference in Hormone Levels?
Gender, Sexual Orientation & Hormones; Hormone Replacement Therapy
Aromatization; Steroid Hormones & Gene Expression
Kids & Changing Gender Identity
Sexual Behavior, Refractory Period & Male Brain, Tacr1 Cells
Sponsor: Function
Hypothalamus, Dopamine, Prolactin, Cabergoline, Libido, Dopamine
Brain Circuits, Aggression & Sexual Behavior
Refractory Period; Age, Testosterone & Libido
Tacr1 Cells in Females, Periaqueductal Gray & Innate Behaviors
Parenting Behaviors & Brain Circuits; Pet Dogs
Oxytocin, Pair Bonding, Vasopressin; Biological Redundancy
Libido, Melanocortin, Tacr1 Neurons; GLP-1 Agonists, Clinical Trials; Kisspeptin
Female Brain Changes, Menstrual Cycle, Pregnancy, Menopause; Estrogen; Men & Hormone Fluctuation?
Life Experience Male vs Female, Sex Recognition, Behaviors & Context
Pain Management; Endocrine Disrupters, Gender Identity
Future Projects
Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter
0:00
2:26:58
Download MP3
Show notes
My guest is Dr. Nirao Shah, MD, PhD, a professor of psychiatry, behavioral sciences and neurobiology at Stanford University School of Medicine. We discuss how the brains of males and females differ and how those differences arise from different genes and hormones during fetal development, in childhood and adulthood. We discuss what drives male- versus female-specific behaviors and how hormonal fluctuations across the lifespan, including puberty, the menstrual cycle, menopause and aging – affect behavior, cognition and health. Additionally, we discuss how biology relates to gender identity and the impact of hormone therapies on brain circuits that regulate mating, parenting and social bonding.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Maui Nui: https://mauinuivenison.com/huberman
Eight Sleep: https://eightsleep.com/huberman
LMNT: https://drinklmnt.com/huberman
Function: https://functionhealth.com/huberman
Timestamps
Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices