Huberman Lab
Huberman Lab
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Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy
2 hour 44 minutes Posted Jul 21, 2025 at 8:00 am.
Chris McCurdy
Kratom (Mitragyna speciosa), Origin, Effects, Low vs High Doses
Sponsors: David Protein & Eight Sleep
Kratom, Traditional Use vs Commercial Kratom Products, Absorption
Kratom Products, Serving Size, Kids; Semi-Synthetics; Tool: Understand Kratom Product Labels
Kratom Products & Various Desired Effects; Physical Dependence
Different Kratom Usage Patterns, Opioid Dependence
Alkaloid Compounds, Nitrogen, Nicotine; Animals & Self-Experimentation
Sponsors: AG1 & ROKA
Medicine Development, Disconnection from Nature, Product Concentrations
Alkaloids & Natural Products, Opium Poppy, Coca Leaf, Tool: Kratom Leaf vs Extracts (Kratom-Derived/Kratom Isolates)
Is It Safe for Kids to Consume Kratom Products?
Kratom, Energy, Mood & Pain Management, Dose; Caffeine
Respiratory Depression & Kratom Products
Sponsor: Function
Kratom Leaf vs Derivatives, FDA Regulations, Usage Guidelines
Kratom, Alcohol Consumption, Respiratory Failure?
Kratom Alkaloids, Mood & Stimulant Effects, Multiple Pathways for Pain Relief
Plant Alkaloids & Chemical Defense, Kratom & Antifungal Alkaloids; Geckos
White, Red & Brown Vein Kratom, Leaf Processing; Terpenes
Kratom as an Anti-Depressant?; Discontinuing Kratom Use, Opioid Use
Kratom, Drug Interactions & Seizure, Opioids
Cacao Beans, Chocolate
Coca-Cola, Coca Plant & Cocaine, History of Soft Drinks
Career Journey, Pharmacy, Chemistry & Education, Lobelia
Nicotine; Natural Products & Career Journey, Salvia divinorum, Kratom
Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter
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Show notes
My guest is Dr. Chris McCurdy, PhD, FAAPS, professor of medicinal chemistry at the University of Florida and a world expert on the pharmacology of kratom and other plant-derived medicinal compounds. We discuss kratom’s wide-ranging effects, including its use for boosting energy, enhancing mood, managing pain and as a potential opioid substitute, while also explaining its critical safety concerns and addictive potential, especially for kratom-derived/isolate products. We also discuss plant-based compounds more generally for their potential benefits and risks. Dr. McCurdy offers a balanced perspective on kratom and other plant-based and naturally occurring medicinal compounds, highlighting and contrasting their promise for human health with potential serious risks.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
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Eight Sleep: https://eightsleep.com/huberman
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Function: https://functionhealth.com/huberman
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