Show notes
In this journal club episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins-trained physician focusing on healthspan and lifespan and the host of The Drive podcast.We each present a peer-reviewed scientific paper chosen because it contains novel, interesting, and actionable data. First, we discuss a paper on how bright light exposure at sunrise and throughout the day and dark exposure at night independently improve mental health and can offset some of the major symptoms of mental health disorders such as depression and anxiety. Then, we discuss an article that explores a novel class of immunotherapy treatments to combat cancer. We also discuss some of the new data on low-calorie sweeteners and if they are safe. This episode should be of interest to listeners curious about maximizing their vitality and longevity and to anyone seeking science-supported ways to improve mental health and lifespan.Read the full shotes for this episode at hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanLMNT: https://drinklmnt.com/hubermanlabTimestamps00:00:00 Dr. Peter Attia, Journal Club00:02:56 Sponsors: LMNT & Waking Up00:07:14 Light, Dark & Mental Health; Retina00:11:16 Outdoor vs. Indoor Light, Cataracts, Sunglasses00:16:17 Tools: Sunrise & Sunsets, Circadian Rhythm; Midday Light00:24:55 Tools: Night & Light Exposure; Waking Before Sunrise00:31:05 Article #1, Light/Dark Exposure & Mental Health00:32:36 Sponsor: AG100:38:18 Odds Ratio, Hazard Ratio00:45:43 Night vs. Daylight Exposure, Mental Health Disorders00:51:35 Major Depression & Light Exposure; Error Bars & Significance01:00:39 Prescriptions; Environmental & Artificial Light; Red Lights01:08:14 Nighttime Light Exposure; Sleep Trackers & Belief Effects01:13:54 Light Directionality, Phone, Night01:17:21 Light Wavelengths & Sensors; Sunglasses01:20:58 Hawthorne Effect, Reverse Causality, Genetics01:26:26 Artificial Sweeteners, Appetite01:31:16 Natural Light Cycles, Circadian Rhythm & Mental Health01:39:53 Article #2, Immune System & Cancer01:43:18 T-Cell Activation; Viruses01:50:41 Autoimmunity; Cancer & Immune System Evasion02:00:09 Checkpoint Inhibitors, CTLA-402:06:45 Anti-CTLA-4 Study Drug Ipilimumab, Melanoma02:12:07 Patient Population, Randomization, GP10002:18:09 Response Rate02:22:52 Overall Survival & Response02:28:38 Median Survival vs. Overall Survival, Drug Development02:35:45 Gender & Dose02:40:32 Adverse Events; Autoimmunity02:46:42 Pancreatic Cancer; Aging & Immune System Health02:53:57 Melanoma; Lynch Syndrome, Keytruda02:58:43 Immunotherapy & Cancer Treatment; Melanoma Risk03:06:26 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network NewsletterDisclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices