Huberman Lab
Huberman Lab
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Journal Club With Dr. Peter Attia | Metformin for Longevity & the Power of Belief Effects
2 hour 18 minutes Posted Sep 11, 2023 at 8:00 am.
In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity."We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways.First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose.Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings.For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanLMNT: https://drinklmnt.com/hubermanlabWaking Up: https://wakingup.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps
Dr. Peter Attia, Journal Club
Sponsors: LMNT & Waking Up
Dreams
Article #1, Metformin, Mitochondria, Blood Glucose
Type 2 Diabetes & Causes, Insulin Resistance
Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study
Sponsor: AG1
TAME Trial; Demographics, Twin Cohort
Metformin & Mortality Rate
Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power
Hazard Ratios, Censoring
Metformin Advantage?, Variables, Interventions Testing Program
Berberine, Acarbose, SGLT2 Inhibitors
Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers
Tool: Reading Journal Articles, 4 Questions, Supplemental Information
Article #2, Belief Effects vs. Placebo Effect
Nicotine Effects
Nicotine Doses & Belief Effects, fMRI Scan
Biological Effects, Dose-Dependent Response & Belief Effects
Biology & Beliefs, Significance, Dopamine Response, Non-Smokers
Dose-Dependence & Beliefs, Side Effects, Nocebo Effect
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Show notes
In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity."We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways.First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose.Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings.For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanLMNT: https://drinklmnt.com/hubermanlabWaking Up: https://wakingup.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps(00:00:00) Dr. Peter Attia, Journal Club(00:03:43) Sponsors: LMNT & Waking Up(00:06:11) Dreams(00:12:36) Article #1, Metformin, Mitochondria, Blood Glucose(00:19:47) Type 2 Diabetes & Causes, Insulin Resistance(00:25:30) Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study(00:36:37) Sponsor: AG1(00:37:15) TAME Trial; Demographics, Twin Cohort(00:44:27) Metformin & Mortality Rate(00:51:28) Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power(01:02:23) Hazard Ratios, Censoring(01:09:00) Metformin Advantage?, Variables, Interventions Testing Program(01:16:02) Berberine, Acarbose, SGLT2 Inhibitors(01:23:48) Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers(01:32:22) Tool: Reading Journal Articles, 4 Questions, Supplemental Information(01:38:10) Article #2, Belief Effects vs. Placebo Effect(01:45:22) Nicotine Effects(01:51:07) Nicotine Doses & Belief Effects, fMRI Scan(02:00:07) Biological Effects, Dose-Dependent Response & Belief Effects(02:05:14) Biology & Beliefs, Significance, Dopamine Response, Non-Smokers(02:10:57) Dose-Dependence & Beliefs, Side Effects, Nocebo Effect(02:19:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social MediaDisclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices