In this episode, my guest is Robin Carhart-Harris, PhD, distinguished professor of neurology and psychiatry at the University of California, San Francisco. He is one of leading researchers in the study of how psychedelics such as psilocybin, LSD and DMT can change the human brain and in doing so, be used to successfully treat various mental health challenges such as major depression, anorexia, obsessive-compulsive disorder (OCD) and addiction. He explains how psilocybin induces sustained changes in adaptive brain wiring and cognition. We discuss the key components of safe and effective psychedelic journeys, the role of hallucinations, the use of eye-masks to encourage people to “go internal,” and music, as well as what effective therapist support consists of before, during and after the session (also known as integration). We discuss micodosing vs. macrodosing and how researchers control for placebo effects in psychedelic research. We also discuss the current legal landscape around psychedelic therapies. Psychedelic therapies are fast emerging as powerful and soon-to-be mainstream treatments for medical health disorders, but they are not without their risks. As such, this episode ought to be of use to anyone interested in brain plasticity, mental health, psychology or neuroscience.For the full show notes, visit hubermanlab.com.Thank you to our sponsorsAG1: https://athleticgreens.com/hubermanLMNT: https://drinklmnt.com/hubermanlabWaking Up: https://wakingup.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps

Dr. Robin Carhart-Harris

Sponsors: LMNT & Waking Up

The Brain-Body Contract

Origin of the Word: “Psychedelics”; Pharmacology

Psychedelics & Revealing the Unconscious Mind, Psychotherapy

Microdosing

Psilocybin vs. Magic Mushroom Doses

“Psychedelic-Therapy”, Music

Sponsor: AG1

Psychedelic Journey: “Trust, Let Go, Be Open”

Negative Emotions, Fear & Psychedelics

Global Functional Connectivity, Serotonin 2A Receptor; Subjective Experiences

Pharmacology: Therapeutics without Psychedelic Effects; SSRIs

Psilocybin & Depression; Long-Term Effects: Connectivity & Neuroplasticity

Psilocybin Therapy & Anorexia

Integration Phase & Psychedelic-Therapy; Meditation

First-Time Psychedelic Use, “Entropic Brain Effect”, Neuroplasticity, Cognition

Fibromyalgia & Psychedelic Treatment; MDMA Therapy & “Inner Healer”

Placebo Response & Psychedelic Therapy

LSD & Psychedelic-Therapy, Micro-Dose

Combination Psilocybin-MDMA Therapy

DMT “Rocketship” & Serotonin 2A Receptors; Ibogaine

“Ego Dissolution”, Cocaine vs. Psychedelics; Relapses

Psychedelics & Legal Landscape; Decriminalization

MDMA, Trauma & Clinical Trials; Future Regulatory (FDA) Approval?

Psilocybin & Current Clinical Trials

Mental Health & Psychedelic Treatment, Safeguards, Paradigm Shift