My guest is Sara Gottfried, M.D., a Harvard-trained, board-certified gynecologist and clinical assistant professor of integrative medicine & nutritional sciences at Thomas Jefferson University. Dr. Gottfried specializes in hormone health, vitality and longevity using precision/personalized approaches. We discuss female hormone health, puberty, perimenopause, and menopause, hormone testing, the microbiome, stress related hormone challenges, their causes, and various treatments. We also discuss fertility, birth control and tools for improving microbiome health, treating PCOS, insulin management, and the best nutrition, supplementation, and exercise programs for women. While the episode focuses mainly on female hormones, males will also  benefit from our discussion because it includes  actionable tools suggested for managing stress, bolstering the gut microbiome, and immunity—all of which stand to improve overall health, vitality and longevity in males and females.For the full show notes, visit hubermanlab.com.Thank you to our sponsorsAG1: https://athleticgreens.com/hubermanLMNT: https://drinklmnt.com/hubermanlabWaking Up: https://wakingup.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps

Dr. Sara Gottfried

Sponsor: LMNT

Women, Family History, Heredity & Environment

Puberty, Stress, Menstrual Cycles, Intrauterine Devices (IUDs)

Tool: Sex Hormones, Microbiome, Estrobolome & Disease; Biomarker Testing

Nutritional Testing; Vegetables, Microbiome & Disease

Sponsor: AG1

Microbiome, Prebiotics & Probiotics, Inflammation

Microbiome Testing, Magnesium, Constipation & Thyroid

Female Colonoscopy; Network Effect & Modern Medicine, Stress Factors

Constipation, Stress & Trauma, Autonomic Balance

Constipation Relief, Stress, Breathwork & Meditation

Systemic & Societal Stress Unique to Females

Testing & Future Behavior

Polycystic Ovary Syndrome (PCOS) & Cardiometabolic Disease; Stress

PCOS, Insulin, Glucose Monitoring and Management; Data Access

Behaviors for Vitality; Exercise & Body Phenotype; Cortisol

Cortisol Supplements: Ashwagandha, Rhodiola, Fish Oil, Phosphatidylserine

Cortisol, Anxiety & Immune System; Adrenal Function, Resilience

Tool: Omega-3 Fatty Acids, Inflammation, Specialized Pro-Resolving Mediators

Oral Contraceptives, Benefits & Risks; Ovarian Cancer; Testosterone

Fertility, Follicular & Anti-Mullerian Hormone (AMH) Assessments

Menopause & Hormone Replacement Therapy; Women’s Health Initiative

Perimenopause, Cerebral Hypometabolism, Metabolism & Estrogen

Intermittent Fasting, Ketogenic Diet, Metabolic Flexibility

Stool Testing

Coronary Artery Calcium (CAC) Test, ACE Score & Disease