ZOE Science & Nutrition
ZOE Science & Nutrition
ZOE
How to drink alcohol without destroying your health | Prof. David Nutt
52 minutes Posted Jan 8, 2026 at 12:06 pm.
Intro
Humans have been drinking for 40,000 years here’s why
Why your first drink feels good and the next ones don’t
You don’t need addiction to be harmed
Alcohol ranked worst out of 20 drugs
Why alcohol beats heroin on total harm
Alcohol is toxic — in the same way disinfectant is
The ‘pickling’ process happening inside your body
How alcohol quietly damages your arteries
The fastest way to lower blood pressure
Will your cholesterol drop if you stop drinking?
The red wine myth people still believe
Is any amount of alcohol actually ‘worth it’?
When alcohol may still make sense socially
What a ‘unit’ actually looks like
Why harm rises much faster than you expect
A bottle a day can cost you years of life
Why alcohol helps you fall asleep then wrecks it
What a hangover really is (it’s not dehydration)
Does alcohol actually shrink your brain?
The long-term brain study people ignore
When stopping suddenly can be dangerous
The single rule that stops most people overdrinking
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52:21
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Show notes
Dry January often raises big questions: how much alcohol is actually safe, and do you need to stop drinking altogether to protect your health? In this episode, world-leading alcohol expert Professor David Nutt explains why alcohol ranks as one of the most harmful drugs to society, how even “normal” drinking can affect your health, and what the science really says about cutting back without giving it up completely.
David, a neuropsychopharmacologist and former UK government drug adviser, explains why alcohol was ranked the most harmful drug overall in a landmark comparison of 20 drugs, how harm rises sharply as drinking increases, and unpacks common beliefs like red wine being “good for you”. The conversation also covers the social benefits of alcohol and why the goal isn’t necessarily to stop drinking, but to drink with awareness.
If you drink at all - whether it’s a glass most nights or more on weekends - this episode helps you understand where the real risks begin, and how to make alcohol work for you, not against you. And for listeners using dry January as a reset, David shares practical, science-based advice on how to cut down safely and sustainably.
If you’re pausing and reflecting this dry January, what might change when you start drinking again? And which habits are worth leaving behind for good?
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Mentioned in today's episode
Drug harms in the UK: a multicriteria decision analysis, The Lancet (2010). 
Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study, The Alzheimer's Association (2018)
Feasibility of detection and intervention for alcohol-related liver disease in the community: the Alcohol and Liver Disease Detection study (ALDDeS), British Journal of General Practice (2013)
Drink?: The New Science of Alcohol and Your Health by Professor David Nutt (2020)
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Episode transcripts are available here.