TWiM highlights viral defense and counter-defense: cGAS mediated ubiquitination to counter infection, and viral sponges that sequester nucleotide signals to inactivate immunity.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin.

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• Ubiquitin-like conjugation by bacterial cGAS (Nature)
• Jumpin’ Jack Flash (TWiV 222)
• Viral sponges inactivate anti-phage immunity (Trends Micro)
• cGAS and CD-NTase enzymes (Curr Opin Struct Biol)
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Music used on TWiM is by Ronald Jenkees

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