The Curbsiders Internal Medicine Podcast
The Curbsiders Internal Medicine Podcast
The Curbsiders Internal Medicine Podcast
#494 C. diff, Diarrhea, the Microbiome, and New Therapies with Dr. Cynthia Sears. Live from Johns Hopkins Grand Rounds
57 minutes Posted Aug 11, 2025 at 9:40 am.
Intro
Guest bio and hobby
Case of Charles Fleur Fontaine
Risk factors and epidemiology
Antibiotic hierarchy of risk
Diagnosis, testing strategies
Defining severity
Treatment options
Microbiome recovery strategies
Probiotics and postbiotics
Infection control counseling
C. diff and colon cancer
Recurrent C. diff strategies
Why some FMT and bezlotoxumab were discontinued
Microbiota replacement therapies
Prophylaxis strategies
Future therapies and ongoing research
Audience Q&A
Outro
0:00
57:50
Download MP3
Show notes
Dominate C. diff! Learn to distinguish colonization from infection, select first-line therapies, and counsel patients on recurrence prevention and microbiome recovery. We’re joined by IDSA past president and expert on foodborne and intestinal infections, Dr. Cindy Sears (Johns Hopkins University) for a comprehensive update on Clostridioides difficile (C. diff, Cdiff, CDAD, CDI).
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Show Segments
Credits
Written and Produced by: Matthew Watto, MD, FACP 
Cover Art and Infographic by:
Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP   
Reviewer: Sai S Achi MD,MBA,FACP
Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
Technical Production: PodPaste
Guest: Cynthia Sears MD
Disclosures
Dr. Sears reports no relevant financial disclosures. Dr. Williams financial relationships disclosed include a Merck grant or research support. This relationship has not ended.
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