In an encore of one of our top episodes ever, Dr. Zoffness is back to chat about her brand new book, Tell Me Where It Hurts. PAIN. What is it? Where does it come from? And how can we hurt less? Which hurts more, a kidney stone or heartache? Why does chronic pain persist? Can we turn down our pain dials? To answer these huge questions, pain psychologist Dr. Rachel Zoffness enthusiastically explains the brain, pain and how to retrain it. She is an unabashed neuronerd and a ray of hope in a field that is misunderstood, neglected and under-explained. A true life-changer of a person.

Neurodivergence and weed. Munchie remedies. Long term toking. The Entourage Effect. Drag a bean bag into the circle and kick back for Part 2 of Cannabinology with UCLA’s Center for Cannabis and Cannabinoids director Dr. Ziva Cooper and Smith College cannabis anthropologist Dr. Caroline Melly. We’ll probe the great mystery and misfortune of hyperemesis, the effect of THC on memory and neuroplasticity, why edibles sometimes send you to a distant galaxy, CBD and inflammation, the risks of psychosis, older vs. younger brains and cannabis, a guy named Rick Simpson, how much weed is the right amount of weed, and if any studies warrant further research. Heads up: they do.

Gummies vs. pre-rolls. THC vs. CBD. Indica vs. sativa. Hemp vs. marijuana. Dad grass vs. modern trees. This extended 2-part deep dive with UCLA’s Center for Cannabis and Cannabinoids director Dr. Ziva Cooper and Smith College cannabis anthropologist Dr. Caroline Melly covers the storied history of the weed’s trek across continents, the endocannabinoid system, the “bliss” molecule,” brain receptors, cancer therapeutics, edible mishaps, the munchies, legalization, titration, addiction, kief, hash, dabs, shatter, strains, and so much more.

Discovery. Drama. Diversity. Design inspo. Let’s squirm into the sea grass and the tidal crevices with California Academy of Sciences legend Dr. Terry Gosliner and the American Museum of Natural History’s Dr. Jessica Goodheart to discover bunny horns, finger backs, stolen weaponry, “buttflowers,” doomed first dates, high fashion, tiny eyes, gender fluidity, “Finding Nemo” cameos, the boardgame you need, and how your phone can warm a scientists heart just by slipping on a windbreaker and looking for beautiful things.

Cheetahs. Tigers. Jaguars. Pumas. Panthers. Snow leopards. How big is a big cat? And who decides? Let’s ask the charming wildlife biologist, science communicator, and Megafelinologist Dr. Imogene Cancellare. She shares tales of remote field work, snow-capped mountains, narrow escapes, camera trap revelations, DNA discoveries, brinks of extinction, if big cats like big boxes, why tails can be bobbed, lioness manes, big cat attacks, and making huge biscuits. Also: how to make your cats *Obsessed* with you.

Dander enemies. Gluten intolerances. Runny noses. Shellfish bummers. Skin prick tests. Epipen pockets. Allergies? WE GOT ‘EM, folks. And we’ve got double board-certified allergist, immunologist, and author of the New York Times Bestseller “All About Allergies” Dr. Zachary Rubin. The Doc takes a quick break from his many demanding jobs to let me pepper him with questions about sneezing, allergy shots, Benadryl naps, home testing vs. office visits, oral challenges, unfriendly fruits, street tree sexism, and so much more. We’ve been itching to do this one for a while, so get it in your system ASAP.

Come check out my butt with me (again)! 1 in 16 people in the U.S. will have colon cancer, and 0 in 16 want to talk about getting a camera up your guts to check things out. I am one of them, but after losing loved ones to colon cancer – and staring down the barrel of my first-ever colonoscope — I recorded tips, tricks, taste tests, foggy drug hazes, bar room advice, and finally my surprising results. It may save a life. Possibly yours.

So, you don’t want colon cancer, but you DO want buttsex secrets? Have we got an episode for you. Coloprotocolgist Dr. Carmen Fong charms us in a brand-new episode about prostate orgasms, shady polyps, fibermaxxing, colon cancer branding, butt plugs, heartburn, douches, bidets, farts, vacation constipation in the nation, ostomy awareness, second sphincters, Crown Jewels, pregnancy agonies, ‘roids, fissures, fixes, endometriosis, diverticulitis, IBS, hydrotherapy, a shocking shower revelation, and how a blissful colonoscopy could change and save your life.

Our Culcitology (QUILTS) episode taught you why quilts are agents of rebellion, community, and chill vibes all in one. This bonus episode will tell you how to start and how to dive into anything creative without freaking out first, featuring advice from Joe Cunningham and Kule Haynes, plus dozens of friendly Ologies listeners/quilters. Cut up some scraps, pick up a needle, and make something. You never know where it might lead you, and who it could help in the future. Including you, kiddo.

Is anything real? How many universes are there? Is everything a simulation being run by a quantum computer through a wormhole from a future era? Is the answer to everything really ... 42? The affable and charming astrophysicist, author and philosopher of tiny particles Dr. Adam Becker pulls up a seat. And enjoy this encore episode as Alie has an existential crisis or two as they discuss the drama, intellectual battles and drunken debates of science past, and the hope that a new era of thinkers will figure out what exactly is going on in the world. Either way: cut bangs and text your crush.