Sam Harris speaks with James Fadiman about the psychedelic experience. They discuss who should and shouldn't take psychedelics, set and setting, the role of a guide, the effects of microdosing, the difference between MDMA and true psychedelics, "good" and "bad" trips, the power of thought, the fiction of a unified self, changing states of self, compassion, and other topics.

If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.