The Immune team goes up the nose to discuss cytotoxic T cells activating complement through secretion of granzyme K to drive inflammatory nasal polyps and how IgA-producing B cells are made in the nose. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server CD8 T cells in recurrent airway inflammation (Nature 2025) Where IgA producing B cells arise that protect the nose (Nature 2024) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.  

From the 2024 Society for Leukocyte Biology meeting, Cindy and Brianne talk with Darren Lee to discuss his career, how he got interested in immunology of the eye, and how his team visualizes immune responses of the eye in real time with the hope of better understanding autoimmune uveitis. Hosts: Cindy Leifer and Brianne Barker Guest: Darren Lee Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server The eye is an immunosuppressive environment (Adv Drug Delivery Rev 2023) Tregs control autoimmune uveitis (Sci Rep 2025) TIGIT, Tregs, and autoimmune uveitis (J Leuk Biol 2024) Society for Leukocyte Biology Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Vincent and Cindy discuss differences between MPox-specific T cell responses following infection and vaccination, and lymph node macrophage control of memory B cell localization and trafficking that might be important for choosing which arm to get a vaccine. Hosts: Vincent Racaniello and Cindy Leifer Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Different T memory response to MPox infection or vaccination (Nat Comm 2025) Macrophages direct B cell recall responses after vaccination (Cell 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

From the 2024 Society for Leukocyte Biology meeting, Cindy and Brianne sit down with Justin Wilson to talk about how he got into research and his more recent studies on innate immune sensors and the interaction between the gut microbiome and inflammation related to inflammatory bowel disease and cancer. Hosts: Cindy Leifer and Brianne Barker Guest: Justin Wilson Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Francisella tularensis undermining macrophage defenses (Infect Immunity) AIM2 suppressing colon cancer (Nature Med) NLRP12 regulates gut microbiota homeostasis (Cell Host Microbe) Oral bacteria and carcinogenesis connection (Microbiol Mol Bio Rev) Society for Leukocyte Biology Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Steph talks about identification of gut bacteria that can digest protective mucosal antibodies and Vincent covers a new paper on Zika virus that implicates fetal phagocytes in brain invasion, which may provide insight into the devastating microcephaly outcome of infection during pregnancy. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Gut bacteria induce mucosal immunodeficiency (Science) Contribution of fetal mononuclear phagocytes to Zika virus neuroinvasion (Cell) TWiV468 discusses Zika and brain slice infection model. Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

From the 2024 Society for Leukocyte Biology meeting, Immune talks with Holger Heine about the discovery of immune recognition of bacterial lipopolysaccharide and innate immunity to organisms within the kingdom Archaea. Hosts: Cindy Leifer and Brianne Barker Guest: Holger Heine Become a patron of Immune! Links for this episode MicrobeTV Discord Server TLR8 recognizes human gut-associated archaeon (Front Immunol) The human archaeome and its relevance for health and disease (FEBS) Structural insights into TLR4 recognition of synthetic LPS mimetics (Nature Comm) Society for Leukocyte Biology Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Immune talks with David Peterson and Kim Klonowski from the University of Georgia about their careers, their People, parasites, and plagues podcast, placental malaria immunity, and and how interferons in the thymus affect T cell repertoire selection. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Guests: David Peterson and Kim Klonowski Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server People, parasites, and plagues podcast Placental malaria and circumsporozoite protein-specific immunity (Trends in Parasitology) Sterile production of interferons in the thymus affects T cell repertoire selection (Science Immunology) Dickson Despommier’s book People Parasites and Plowshares Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

From the 2024 Society for Leukocyte Biology meeting, Immune talks with Amy Hise about her career in science, her current research using mouse models for investigating fungal immunity and navigating the challenges of being a mom in science. Hosts: Cindy Leifer and Brianne Barker Guest: Amy Hise MicrobeTV Discord Server Mouse model for testing drugs to treat Candida fungal infection Inflammasomes in Aspergillosis Society for Leukocyte Biology Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Content in this podcast should not be construed as medical advice.

Immune 90: Immunology of Injury March 25, 2025 From the 2024 Society for Leukocyte Biology meeting at Michigan State University, home of the Spartans, Immune’s Cindy and Brianne talk with Liz Kovacs and Jim Lederer about their careers, dirty mice, old mice, and immunity during trauma. Hosts: Cindy Leifer and Brianne Barker Guests: James Lederer and Elizabeth Kovacs Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Jim Lederer’s Neutrophil trained immunity and Trauma effects on immune cells Liz Kovacs’s Aging and lung inflammation and Alcohol effects on burn patients Paper on use of “dirty mice” also known as natural immune mice Society for Leukocyte Biology Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Immune Booster #10 HIV in the brain with Amanda Brown March 18, 2025 From the The Society for Leukocyte Biology 2024 conference at Michigan State University, Cindy and Brianne sit down with Amanda Brown from Johns Hopkins School of Medicine to talk about her career and the research of her laboratory on mechanisms of neuroinflammation in disease, especially during HIV infection. Hosts: Cindy Leifer and Brianne Barker Guest: Amanda Brown Society for Leukocyte Biology Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Content in this podcast should not be construed as medical advice.