Melissa and Jam explore the concept of ozone and its impact on air quality in airplanes. Melissa explains the chemical reaction of ozone, why it's significant in organic chemistry, and how it can lead to discomfort in air travel by interacting with the oils on our skin. They also discuss various tips for flying and the potential benefits of noise-canceling headphones and lounge access for frequent flyers. The episode sheds light on why people often feel unwell on planes, highlighting the Pigpen Effect, where leftover oils from previous passengers can react with ozone to create a micro-cloud of pollutants.