Melissa and Jam dive deep into the topic of FDA regulations, particularly focusing on food additives like red food dye. They discuss the complexities of the FDA's approval process, the Delaney Clause, and recent changes in the regulation of red dye number 3, which has been banned in response to cancer risks found in rats. They also delve into how other countries like the UK and Canada are ahead of the U.S. in reevaluating approved substances. The episode includes personal anecdotes and a discussion on the role of public awareness in influencing FDA policies. They wrap up with a lighthearted conversation about sprinkles and favorite dyed foods.