TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode- MicrobeTV Discord Server
- MicrobeTV store at Cafepress
- Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
- VITT-like disorder after adenovirus infection (NEJM)
- The clot thickens (TWiV 842)
- Lessons from VITT (Nat Rev Immunol)
- Pan-sarbecovirus neutralizing mAb (Sci Adv)
- Letters read on TWiV 1037
- Timestamps by Jolene. Thanks!
Dickson – Rho Ophiuchi nebula showing massive star formation. James Webb Space Telescope Brianne – Question Mark in Space? Kathy – Quammen interview with Walter Isaacson Rich – Chrome Music Lab Vincent – Matters Microbial
Listener PicksTom – The (second) deadliest virus Charles – We Will All Go Together When We Go and So Long Mom (A Song for World War III) Intro music is by Ronald Jenkees
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