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As he finished his medical residency exam, David Fajgenbaum felt off.  He walked down to the ER and checked himself in.  Soon he was in the ICU with multiple organ failure.  The only drug for his condition didn’t work. He had months to live, if that.  If he was going to survive, he was going to have to find his own cure. Miraculously, he pulled it off in the nick of time. From that ordeal, he realized that our system of discovering and approving drugs is far from perfect, and that he might be able to use AI to find dozens, hundreds, even thousands of cures, hidden in plain sight, for as-yet untreatable diseases. EPISODE CREDITS:Reported by - Latif NasserProduced by - Maria Paz Gutiérrezwith mixing help from - Jeremy S. BloomFact-checking by - Natalie A. MiddletonEPISODE CITATIONS:Books -Blair Bigham, Death Interrupted: How Modern Medicine is Complicating the Way We DieRadiolab | Lateral Cuts:Check out Death Interrupted (https://radiolab.org/podcast/death-interrupted), a conversation with Blair Bigham about a worldview shifting change of heart. The Dirty Drug and the Ice Cream Tub (https://radiolab.org/podcast/dirty-drug-and-ice-cream-tub) to hear the crazy story about how Rapamycin was discovered.

Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

The Medical Matchmaking Machine

Have you ever fallen asleep in school or during a work meeting? Maybe you felt your eyes glaze over as your boss or a teacher droned on and on about a topic that had no relevance to you. What's missing from these classrooms and conference rooms is engagement: A state of being absorbed, alert, and eager to learn. This week, psychologist and neuroscientist Mary Helen Immordino-Yang explores why so many of us feel apathetic at school and at work, and how to cultivate the magic of engagement.

How Our Brains Learn

In this latest episode of the “More From Sam” series, Sam and Jaron talk about current events and answer some of the questions you all submitted on Substack. They discuss Trump and his attempts at peace deals, Gavin Newsom as the potential 2028 Democratic nominee, rising class tensions and the ethical responsibilities of the ultra-wealthy, DOGE, & rapid fire questions. Produced by Griffin Katz  

#430 — “More From Sam”: Trump, Gavin Newsom, Class War, DOGE, & Rapid Fire Questions

What would it take to actually read someone’s mind? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O’Reilly explore the science and ethics of decoding thoughts with Jean-Rémi King, a neuroscience researcher at Meta’s Paris lab.

Mindreading with Jean-Rémi King

Train tracks. Split decisions. And a philosophy humdinger worth debating. Dr. Joshua Greene is a Harvard Psychology professor, neuroscientist, and *actual* Trolleyologist. This thought experiment pops up in everything from policy discussions to board games and looks at: What makes you a good person? How do you reason with people who make you scream into a jar like Yosemite Sam? How far would you go to save others? Which charities should get your money? What is active versus passive harm? And what would a monk do? Also: how neurodivergence influences moral decisions, religion used as a moral compass, and your new favorite skeleton on the planet.

Trolleyology (MORAL DILEMMAS + THE TROLLEY PROBLEM) with Joshua Greene

In the wake of funding cuts to mRNA vaccine research, we revisit a February story about a promising vaccine for pancreatic cancer.

mRNA Vaccine For Pancreatic Cancer Continues To Show Promise

Aging isn’t just a biological process. Our outlooks and emotions also change as we age, often in ways that boost our well-being. This week, we revisit a favorite conversation with psychologist Laura Carstensen, who helps us unpack the science behind this surprising finding, and shares what all of us can learn from older people. Then, as part of our ongoing series "Your Questions Answered," we revisit our follow-up chat with Laura, who responds to listeners' thoughts and questions and shares more of her research on what it means to live well as we age.

The Best Years of Your Life

Quickie with Steve: Using Fusion to Make Gold; News Items: Older Americans Using AI, Semi-Solid State EV, Ad Hominem Attacks Online, Non-Surgical LASIK, Now 3I-ATLAS is Glowing; Who's That Noisy; Your Questions and Emails: Elemental Drugs; Science or Fiction

The Skeptics' Guide to the Universe

The Skeptics Guide #1050 - Aug 23 2025

Today we are all over the map. First: Elon, AI, and humanoid robots, with discussion of sex, the industrial revolution, specialization, the Pleistocene, feminism, men’s work, porn, clankers, and vaping. Obviously. Then: are there differences between moral panics and social contagions, and is the current focus on pedophilia one or both? Finally: how widespread is fraud in science? It’s not rare, and not merely the result of bad actors. Taking a game theoretic approach, authors of new research ...

Where has all the science gone? The 290th Evolutionary Lens with Bret Weinstein and Heather Heying

In an episode first released in 2010, then-producer Lulu Miller drives to Michigan to track down the endangered Kirtland’s warbler. Efforts to protect the bird have lead to the killing of cowbirds (a species that commandeers warbler nests), and a prescribed burn aimed at creating a new habitat. Tragically, this burn led to the death of a 29-year-old wildlife technician who was dedicated to warbler restoration. Forest Service employee Rita Halbeisen, local Michiganders skeptical of the resources put toward protecting the warbler, and the family of James Swiderski (the man killed in the fire), weigh in on how far we should go to protect one species.

EPISODE CREDITS:Reported by - Lulu MillerSignup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.

Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Weighing Good Intentions

Chocolate may fill grocery store shelves around the world, but the raw product that powers chocolate is far more selective. The majority of chocolate farms are found in West Africa and South America – just 20 degrees north or south of the equator. Each farm produces chocolate of a different flavor. Some cocoa tastes fruitier; others, more floral. Nutty. Earthy. Spicy. But what drives these different flavor profiles? And can it be recreated in a lab? A team led by scientists at the University of Nottingham in the UK sought to find out and published their results in the journal Nature Microbiology this week. Curious about other ways science intersects with food? Email us at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Could labs replace your natural chocolate?

Are we alone in the universe? Neil deGrasse Tyson and comic co-host Matt Kirshen sit down with one of the founders of the SETI Institute, Jill Tarter, to explore the search for intelligent life beyond Earth, technosignatures, The Drake Equation, and more.

Are We Alone? with Jill Tarter

Solar power adoption has been rising fast. Amid recent federal efforts to limit clean energy, will it make a dent in our climate impact?

Can The Rise In Solar Power Balance Out Clean Energy Cuts?

Until recently, scientists assumed humans were the only species in which females went through menopause, and lived a substantial part of their lives after they were no longer able to reproduce. And they had no idea why that happens, and why evolution wouldn’t push females to keep reproducing right up to the end of their lives. But after a close look at some whale poop, and a deep dive into chimp life, we find several new ways of thinking about menopause and the real purpose of this all too often overlooked second act of life.  

Special thanks to Danielle Friedman, Rachel Gross, and Kate Radke.

EPISODE CREDITS: Reported by - Heather Radke and Becca BresslerProduced by - Sarah Qari and Becca BresslerFact-checking by - Emily Kriegerand Edited by  - Becca Bressler

EPISODE CITATIONS:Books - Check out everything Heather Radke writes, including Butts: A Backstory, cause it’s all that good, here: Heather Radke (www.heatherradke.com).

Find any one of Lucy Cooke’s book, including Bitch:On the Female of the Species, here: Lucy Cooke (http://www.lucycooke.tv/)And check out everything Caroline Paul has on offer, including Tough Broad, here:  Caroline Paul (https://www.carolinepaul.com/) Socials - Heather Radke: https://www.instagram.com/radhradkeLucy Cooke: https://www.instagram.com/luckycooke/

Audio:Becca Bressler’s Greatest Hits - Everybody's Got OneThe Shark Inside You Growth

Lateral cuts - Butt Stuff

Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.

Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

The Menopause Mystery

Strange beings appear in the dead of night. Some say they’re aliens, others aren’t so sure. In this episode, we explore unsettling encounters that seem extraterrestrial but may be something far stranger. Through the research of Nigel Watson, we uncover bizarre contact reports and ask whether these visitors come from the stars or from deep within the human mind. 

Then, coming up for our Plus+ members, we dig into eerie outlier cases including ghostly visitations tied to UFO phenomena and the chilling account of Betty Hill’s paranormal experiences that began even before her famous abduction. The deeper you look, the stranger it gets.


  Nigel Watson's Picture Perfect Portraits of Alien Encounters

  Paranormal Perspectives: Portraits of Alien Encounters Revisited: High Strangeness British UFO Cases

  Paranormal Perspectives: Portraits of Alien Encounters Revisited

  Nigel Watson

  Woman claims she's been abducted by aliens 52 times and 'has bruises to prove it'

  Abductee Claims Aliens Gave Her Warnings and Bruises

  Alien Abductee Sets the Record Straight About Her Amazing Encounters



  The Bedroom Invaders

  The Collected Issues of THE A.P.R.O BULLETIN AERIAL PHENOMENA RESEARCH ORGANIZATION

  Captured! The Betty and Barney Hill UFO Experience

  The Ghost and Betty Hill

  John Keel - The Cape May Incident


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Mysterious Universe

34.08 - MU Podcast - Invisible Joy Ride

Some things just go together: peanut butter and jelly, bacon and eggs, milk and cereal, London and smog. Or at least, that&rsquo;s the way things used to be until the Great Smog of 1952. (Don&rsquo;t worry, the first three pairings are safe). If you&rsquo;ve watched The Crown, you may remember an early episode in which a thick, noxious smog surrounded the entire city of London for days on end. People coughing, hacking, collapsing. Traffic ground to a standstill. Authorities in denial. What was actually going on in December 1952 to lead to such conditions? What was in the smog to make it so toxic? And how did this severe pollution event lead to massive changes in air quality regulations around the world? Tune in to find out all this and more (including what The Crown got wrong). Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAuSee omnystudio.com/listener for privacy information.

Ep 185 The Great Smog of London: “Thick, drab, yellow, disgusting”

In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses outbreaks of Vibrio vulnificus and Legionnaire’s disease in Harlem, the role of the American Association of Pediatrics defining immunization practices, before Dr. Griffin deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, effective of the high and low does influenza vaccines, association Gullian-Barre syndrome with RSV vaccination, guidelines for using RSV vaccines, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, vascular aging after COVID-19 and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Department of Public Health alerts public to rare Vibrio vulnificus bacteria in coastal waters (Mass.gov) Legionnaires’ Disease: In Harlem (NYC Health) Ivermectin to Control Malaria (NEJM) AAP has been leading voice on childhood vaccine recommendations since 1930s (American Academy of Pediatrics) The American Academy of Pediatrics Releases Its Own Evidence-Based Immunization Schedule (American Academy of Pediatrics) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Weekly measles and rubella monitoring (Government of Canada) Health Ministry says unvaccinated 18-month-old dies of measles (Times of Israel) Ten countries in the Americas report measles outbreaks in 2025 (PAHO: Pan American Health Organization) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles vaccine recommendations from NYP (jpg) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola)) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to frailty score (JID) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) RSV: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) ENFLONSIA: novel drug approvals 2025 (FDA) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Evaluation of Guillain-Barré Syndrome (GBS) following Respiratory Syncytial Virus (RSV) Vaccination Among Adults 65 Years and Older (FDA) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Paxlovid (Pfizer) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study (European Heart Journal) Reaching out to US house representative Letters read on TWiV 1246 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.

This Week in Virology

TWiV 1246: Clinical update with Dr. Daniel Griffin

Spoke to the witness who is from Oklahoma and he said “I saw the creature on two different occasions in broad daylight. What I saw looked like a cave man. I was a young man when this encounter took place, I was frozen looking at this thing. Later that night it came to my window. I have seen so much over the years on this property. I learned many years ago to keep my mouth shut because of ridicule. I recently received some bad news from my doctor, I don’t care anymore what people think. A friend of my mine recommend your podcast.”

SC EP:1180 The Caveman On The Property

In this episode, we unpack the explosive research that set the world news cycle ablaze this spring. Andrew Jones and his team produced groundbreaking geophysical scans and soil analyses in Eastern Turkey, suggesting the legendary Noah’s Ark may have been found. Join us as we dive into the murky ground of Turkey’s Durupinar formation with the founder of Noah’s Ark Scans.

We go deep into the mountains of Eastern Turkey to explore what could be humanity's greatest archaeological discovery.  From Ron Wyatt's pioneering work in the 1970s to the cutting-edge use of ground-penetrating radar, which reveals underground chambers, we examine the compelling evidence at the Durupinar Formation. Could this 515-foot boat-shaped anomaly, sitting exactly 300 cubits long, really be Noah's Ark? We discuss the advanced ship design, soil analysis showing 3x higher organic matter inside the formation, mysterious drogue stones scattered nearby, and the controversial giant graves that have vanished with their golden treasures.  Is this the fossilized frame of the Ark, or has nature played masterful mimic? 

Come along on this incredible journey to the Iranian border, where ancient history meets modern science and cutting-edge research may uncover the final resting place of Noah's Ark and a link to the Biblical Flood. 



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EP: 350 Noah's Ark Found? The Durupinar Formation Investigation with Andrew Jones

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No one likes making a fool of themselves — but it turns out, it might be one of the best things you can do for your happiness. In this opening segment, we explore how moments of public embarrassment can lead to surprising psychological benefits. It may feel awful in the moment, but research says it could actually improve your well-being in the long run. https://exploringyourmind.com/making-fool-yourself-makes-you-happier/⁠

Everyone lies… but at what cost? When you're caught in a lie, the damage goes beyond embarrassment — it can change how others see you and even how you see yourself. In this fascinating conversation, Drew Curtis, licensed psychologist and faculty member at Angelo State University, explains the psychology of lying. He’s author of Big Liars: What Psychological Science Tells Us About Lying and How You Can Avoid Being Duped (https://amzn.to/47PmsmP), and he reveals why we lie, how it affects our lives, and how to spot deception before it fools you.

The space race is no longer just between nations — now, it's fueled by billionaires, startups, and high-stakes competition. Ashlee Vance, bestselling author of When the Heavens Went on Sale: The Misfits and Geniuses Racing to Put Space Within Reach (https://amzn.to/44gavDB) and feature writer at Bloomberg Businessweek, joins me to explore how private companies are transforming space exploration. Discover who's really leading the charge — and what’s at stake as space becomes the next frontier for profit.

It sounds strange, but the bubbles in your cup of coffee might just give you a hint about the day’s forecast. In this quick and quirky segment, I explain how to read the signs in your coffee — and the science (sort of) behind it. https://www.instructables.com/Predict-weather-with-a-cup-of-coffee/

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